Description

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol Mesylate is a high-purity, non-racemic chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters as a critical building block for the development of novel antifungal and other active pharmaceutical ingredients (APIs), where its defined stereochemistry is essential for biological activity. It is primarily needed by pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the production of advanced, stereospecific therapeutic agents.

Application

• Key chiral intermediate in the synthesis of advanced triazole-based antifungal APIs.
• Precursor for pharmaceutical research and development of new chemical entities targeting fungal infections.
• Building block for process chemistry in scaling up the production of stereochemically pure drugs.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Starting material for medicinal chemistry programs exploring structure-activity relationships (SAR).
• Intermediate for custom synthesis and contract manufacturing of specialized fine chemicals.

Basic Information

Product Name	(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol Mesylate
CAS No.	1175536-50-1
Molecular Formula	C13H16F2N3O5S
Molecular Weight	364.35 g/mol
Synonyms	(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate; (2R,3R)-2,3-Butanediol, 2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-, methanesulfonate; (2R,3R)-Efinaaconazole Mesylate; (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol mesylate salt; Efinaaconazole Mesylate Intermediate; Jublia® API Intermediate; (2R,3R)-2-(2,4-Difluorophenyl)-1-(1,2,4-triazol-1-yl)butane-2,3-diol mesylate
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol Mesylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. The product undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, stereochemical purity, and impurity profile. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2R,3R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.