Description

2-Chloro-5-Fluorophenylacetyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated phenylacetyl motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro-fluorophenyl group enhances biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating specialized fluorinated organic compounds used in electronic displays and lighting.
• Peptide Mimetics & Bioactive Molecule Research: Employed in medicinal chemistry for the development of peptide analogs and other bioactive molecules.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new chemical reactions involving acid chloride functionalities.

Basic Information

Product Name	2-Chloro-5-Fluorophenylacetyl Chloride
CAS No.	1175028-47-3
Molecular Formula	C8H5Cl2FO
Molecular Weight	207.03 g/mol
Synonyms	2-Chloro-5-fluorobenzeneacetyl chloride; (2-Chloro-5-fluorophenyl)acetyl chloride; 2-Chloro-5-fluoro-α-toluoyl chloride; 2-Chloro-5-fluorophenylacetic acid chloride; α-Chloro-2-chloro-5-fluoroacetophenone (related); 2-Chloro-5-fluorobenzyl carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluorophenylacetyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.