Description

Amg-337 CAS NO 1173699-31-4 is a potent and selective small molecule inhibitor of the mesenchymal-epithelial transition (MET) receptor tyrosine kinase. This compound is critical for targeted cancer research and therapeutic development, specifically in pathways associated with tumor growth and metastasis. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Oncology Research: Used as a key biochemical tool to study MET-driven signaling pathways in various cancer cell lines.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel MET-targeted anticancer therapies.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate the efficacy and mechanism of action of MET inhibition.
• Biomarker Research: Aids in understanding patient stratification and identifying tumors likely to respond to MET inhibitor treatment.
• High-Throughput Screening (HTS): Used as a control compound in assay development and screening campaigns for kinase inhibitor libraries.

Basic Information

Product Name	Amg-337
CAS No.	1173699-31-4
Molecular Formula	C₂₃H₂₀N₆O₂
Molecular Weight	412.45 g/mol
Synonyms	AMG 337; AMG-337; N-[3-Fluoro-4-[[6-(methylamino)-2-pyrimidinyl]oxy]phenyl]-1-(4-fluorophenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide; 1-(4-Fluorophenyl)-N-(3-fluoro-4-((6-(methylamino)pyrimidin-2-yl)oxy)phenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide; MET Kinase Inhibitor AMG-337
EINECS	Contact for details

Quality Control

Our Amg-337 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity and critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.