Description

Oxan-4-Ylmethyl Chloroformate is a specialized chloroformate ester derivative of tetrahydro-2H-pyran-4-methanol, serving as a versatile and reactive chemical intermediate. This compound is particularly valuable for introducing the oxan-4-ylmethyloxycarbonyl protecting group in sophisticated organic synthesis and pharmaceutical manufacturing. It is primarily needed by research institutions and industrial producers engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced organic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly in introducing protecting groups for amines and alcohols.
• Peptide Chemistry: Used as a coupling agent or protecting group reagent in the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and insecticides that require the incorporation of a tetrahydropyran moiety.
• Polymer Science: Serves as a monomer or modifying agent for creating specialty polymers with tailored properties, such as functional polycarbonates or polyurethanes.
• Material Science Research: Employed in surface modification and the creation of novel organic frameworks and dendrimers.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in research applications to study biological processes.

Basic Information

Product Name	Oxan-4-Ylmethyl Chloroformate
CAS No.	1171967-42-2
Molecular Formula	C7H11ClO3
Molecular Weight	178.61 g/mol
Synonyms	Tetrahydro-2H-pyran-4-ylmethyl chloroformate; (Oxan-4-ylmethyl) carbonochloridate; 4-(Chlorocarbonyloxymethyl)tetrahydro-2H-pyran; THP-Protected Chloroformate; Tetrahydropyran-4-ylmethyl Chloroformate; 4-(Hydroxymethyl)tetrahydro-2H-pyran Chloroformate; Oxan-4-ylmethyloxycarbonyl Chloride
EINECS	Contact for details

Quality Control

Our Oxan-4-Ylmethyl Chloroformate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Acid Content (Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.