Description

Gdc-0623 is a potent and selective small molecule inhibitor targeting specific kinase pathways involved in cellular signaling. This compound is a critical research tool for investigating disease mechanisms and developing novel therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology and targeted drug discovery programs.

Application

• Biomedical Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies for cancer research.
• Kinase Profiling: Serves as a selective inhibitor in biochemical and cellular assays to study specific kinase function and signaling networks.
• Drug Discovery & Development: A key intermediate or tool compound in the synthesis and optimization of novel targeted cancer therapies.
• Mechanistic Studies: Employed in vitro and in vivo to validate drug targets and understand resistance mechanisms.
• High-Throughput Screening (HTS): Used as a control compound in screening campaigns to identify new chemical entities with similar activity.

Basic Information

Product Name	Gdc-0623
CAS No.	1168091-68-6
Molecular Formula	C₂₀H₂₅N₅O₂
Molecular Weight	367.45 g/mol
Synonyms	GDC-0623; GDC0623; RG-7421; RG7421; (R)-5-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-((1R,2S)-2-hydroxycyclohexyl)-3-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-1H-pyrazole-4-carboxamide; ARRY-334543 analog; MEK inhibitor GDC-0623
EINECS	Contact for details

Quality Control

Our Gdc-0623 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.