Description

Azido-Peg12-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a carboxylic acid terminus. This compound is a critical reagent for bioconjugation, enabling the controlled, site-specific coupling of biomolecules and materials via click chemistry and amide bond formation. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require precise and stable crosslinking strategies.

Application

• Bioconjugation and ADC Development: Used as a spacer/linker for conjugating antibodies, proteins, or peptides to drugs, toxins, or fluorophores in the synthesis of antibody-drug conjugates (ADCs) and other therapeutic biologics.
• Click Chemistry Reagent: The terminal azide group participates in copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) reactions for labeling, surface functionalization, and polymer modification.
• PEGylation: Serves as a functionalized PEG derivative to introduce hydrophilic PEG chains onto molecules or surfaces, improving solubility, stability, and pharmacokinetic properties.
• Material Surface Modification: Functionalizes nanoparticles, quantum dots, biosensors, and microarray surfaces to create bio-compatible interfaces for diagnostic and research applications.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker to create hydrogels, polymer networks, and biomaterial scaffolds with tailored properties for tissue engineering and drug delivery systems.
• Solid-Phase Peptide Synthesis (SPPS): Incorporated as a building block or used for on-resin modification to introduce PEG spacers and functional handles into synthetic peptides.

Basic Information

Product Name	Azido-Peg12-Acid
CAS No.	1167575-20-3
Molecular Formula	C27H53N3O14
Molecular Weight	643.72 g/mol
Synonyms	Azido-PEG12-Acid; 15-Azido-4,7,10,13-tetraoxa-3-aza-1-pentadecanoic Acid; 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic Acid; N3-PEG12-COOH; Azido-dodecaethylene glycol-carboxylic acid; Azido-PEG12-propionic acid; Azido-PEG12-CH2CH2COOH
EINECS	Contact for details

Quality Control

Our Azido-Peg12-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and functional group integrity as verified by NMR, HPLC, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Identification (IR)	Presence of characteristic azide and acid peaks
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90%
Functional Group Assay (Acid)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.