Description

3,3,3-Trifluoro-2,2-Dimethylpropanoyl Chloride is a high-purity, specialized fluorinated acid chloride building block. This compound is valued for its ability to introduce the bulky, lipophilic, and electron-withdrawing 3,3,3-trifluoro-2,2-dimethylpropionyl group into target molecules, significantly altering their physicochemical properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics where the trifluoromethyl group is desirable.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorinated moiety can improve compound activity, photostability, and rainfastness.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies, where specific fluorine substitution patterns are crucial for tuning electronic properties and stability.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics (low surface energy).
• Peptide & Protein Research: Useful as an acylating agent for modifying amino groups on peptides or proteins, facilitating structure-activity relationship (SAR) studies and the creation of bioconjugates.
• Advanced Material Science: Acts as a reagent for surface functionalization and the creation of specialty coatings with unique hydrophobic and oleophobic properties.

Basic Information

Item	Details
Product Name	3,3,3-Trifluoro-2,2-Dimethylpropanoyl Chloride
CAS No.	1163707-53-6
Molecular Formula	C5H6ClF3O
Molecular Weight	174.55 g/mol
Synonyms	3,3,3-Trifluoro-2,2-dimethylpropionyl chloride; 2,2-Dimethyl-3,3,3-trifluoropropanoyl chloride; Pivaloyl chloride, 3,3,3-trifluoro-; 3,3,3-Trifluoro-2,2-dimethylpropanoic acid chloride; 3,3,3-Trifluoro-2,2-dimethylpropanoyl chloride; TFDPC; 3,3,3-Trifluoro-pivaloyl chloride
EINECS	Contact for details

Quality Control

Our 3,3,3-Trifluoro-2,2-Dimethylpropanoyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.