Description

Ruxolitinib CAS NO 1160597-27-2 is a potent and selective Janus kinase 1 and 2 (JAK1/JAK2) inhibitor. This small molecule pharmaceutical intermediate is critical for the research and development of targeted therapies for myeloproliferative neoplasms and other inflammatory conditions. It is an essential building block for pharmaceutical manufacturers, research institutions, and CROs/CMOs engaged in oncology and immunology drug development.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Primary use as a key intermediate in the commercial production of the JAK inhibitor drug substance.
• Research & Development: Critical for preclinical and clinical studies investigating JAK-STAT pathway inhibition.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical labs.
• Process Chemistry & Scale-Up: Used by process chemists to develop and optimize robust, cost-effective synthetic routes for API manufacturing.
• Drug Discovery: Employed in medicinal chemistry programs for creating novel JAK inhibitor analogs and prodrugs.
• Contract Manufacturing: Supplied to CDMOs for the production of finished dosage forms under cGMP guidelines.

Basic Information

Product Name	Ruxolitinib
CAS No.	1160597-27-2
Molecular Formula	C17H18N6
Molecular Weight	306.36 g/mol
Synonyms	(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; INCB018424; INC424; Jakafi® Intermediate; Jakavi® Intermediate; Ruxolitinib free base; JAK1/JAK2 Inhibitor
EINECS	Contact for details

Quality Control

Our Ruxolitinib is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical R&D and GMP manufacturing. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications are designed to align with ICH Q3A/B guidelines, and we can support customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.