Description

(2,5-Difluoro-4-Nitrophenyl)Methanol is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and a reactive benzylic alcohol group, which enable precise molecular modifications. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and oncology, where fluorine substitution is used to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Employed in the research and development of new-generation herbicides, fungicides, and pesticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, where its structure contributes to desired dielectric and luminescent properties.
• Polymer Chemistry: Used to introduce fluorinated aromatic units into polymer backbones, improving chemical resistance, thermal stability, and surface properties of high-performance plastics and coatings.
• Cross-Coupling Reactions: The aromatic ring is amenable to various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for constructing complex biaryl systems.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and as a standard in analytical chemistry for method development.

Basic Information

Product Name	(2,5-Difluoro-4-Nitrophenyl)Methanol
CAS No.	1160474-68-9
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	2,5-Difluoro-4-nitrobenzyl alcohol; (2,5-Difluoro-4-nitrophenyl)methanol; 4-Nitro-2,5-difluorobenzyl alcohol; 2,5-Difluoro-4-nitrobenzenemethanol; α-Hydroxymethyl-2,5-difluoro-4-nitrobenzene; 1-(Hydroxymethyl)-2,5-difluoro-4-nitrobenzene; Benzenemethanol, 2,5-difluoro-4-nitro-
EINECS	Contact for details

Quality Control

Every batch of (2,5-Difluoro-4-Nitrophenyl)Methanol undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and process development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR and/or NMR), and impurity profiles is provided with each shipment to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.