Description

Sulfamic Acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-Inden-1-Yl]Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl]-2-Hydroxycyclopentyl]Methyl Ester Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound matters as a critical building block in the synthesis of next-generation antiviral therapeutics, offering a defined stereochemical configuration essential for biological activity. Pharmaceutical R&D and manufacturing teams require this advanced intermediate for the development of potent HIV-1 treatments, ensuring a reliable supply of a key chiral synthon.

Application

• Pharmaceutical Active Ingredient (API) Intermediate: A key chiral precursor in the multi-step synthesis of doravirine and related NNRTI drug substances.
• Antiviral Drug Development: Serves as a crucial building block in medicinal chemistry research for novel HIV-1 non-nucleoside reverse transcriptase inhibitors.
• Process Chemistry & Scale-Up: Used in process optimization and kilogram-scale GMP manufacturing for clinical trial material and commercial API production.
• Reference Standard: Employed as an analytical standard for quality control and impurity profiling in API manufacturing.
• Biochemical Research: Utilized in studies investigating the structure-activity relationship (SAR) of antiviral compounds targeting reverse transcriptase.

Basic Information

Item	Details
Product Name	Sulfamic Acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-Inden-1-Yl]Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl]-2-Hydroxycyclopentyl]Methyl Ester Hydrochloride
CAS No.	1160295-21-5
Molecular Formula	C24H28ClN5O5S
Molecular Weight	518.02 g/mol
Synonyms	Doravirine Intermediate; (1S,2S,4R)-Methyl 4-(4-(((1S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentane-1-carboxylate sulfamate hydrochloride; MK-1439 Intermediate; PNU-32945 Intermediate; Lersivirine Related Compound; Sulfamic acid, [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester, hydrochloride; NNRTI Intermediate
EINECS	Contact for details

Quality Control

Our Sulfamic Acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-Inden-1-Yl]Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl]-2-Hydroxycyclopentyl]Methyl Ester Hydrochloride is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, chiral chromatography, NMR, and mass spectrometry, to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all critical quality attributes. Production can be aligned with GMP guidelines for pharmaceutical intermediate applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.