Description

8-Chloro-2-(3-Methoxyphenyl)Quinoline-4-Carbonyl Chloride is a high-value, multi-functional chemical intermediate with significant synthetic utility. Its core value proposition lies in its dual reactive sites—the acid chloride and the chloro-quinoline moiety—which enable efficient derivatization for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require a reliable, high-purity building block for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Serves as a critical building block for creating new pesticides, herbicides, and fungicides with enhanced efficacy and selectivity.
• Material Science: Used in the development of advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: The quinoline core is utilized to create sensitive fluorescent dyes and probes for biochemical sensing and imaging.
• Custom Synthesis & Contract Manufacturing: An important starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	8-Chloro-2-(3-Methoxyphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160263-67-1
Molecular Formula	C18H11Cl2NO2
Molecular Weight	352.20 g/mol
Synonyms	8-Chloro-2-(3-methoxyphenyl)-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 8-chloro-2-(3-methoxyphenyl)-; 2-(3-Methoxyphenyl)-8-chloroquinoline-4-carbonyl chloride; 8-Chloro-2-(3-methoxyphenyl)quinoline-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 8-Chloro-2-(3-Methoxyphenyl)Quinoline-4-Carbonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material manufactured under cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.