Description

(2E)-3-(2-Chloro-6-Fluorophenyl)Acryloyl Chloride is a high-purity, reactive organic intermediate featuring a conjugated α,β-unsaturated acid chloride functional group. This compound is a critical building block in modern organic synthesis, prized for its ability to introduce the (2-chloro-6-fluorophenyl)acryloyl moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated phenyl ring.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored optical or electronic properties.
• Ligand and Catalyst Development: Employed to create novel chiral ligands or organocatalysts for asymmetric synthesis applications.
• Fluorescent Probe Synthesis: Acts as a starting material for constructing fluorophore cores used in bioimaging and diagnostic assays.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	(2E)-3-(2-Chloro-6-Fluorophenyl)Acryloyl Chloride
CAS No.	1160261-55-1
Molecular Formula	C9H5Cl2FO
Molecular Weight	219.04 g/mol
Synonyms	(E)-3-(2-Chloro-6-fluorophenyl)acryloyl chloride; 2-Chloro-6-fluorocinnamoyl chloride; trans-3-(2-Chloro-6-fluorophenyl)-2-propenoyl chloride; (E)-3-(2-Chloro-6-fluorophenyl)prop-2-enoyl chloride; (2E)-3-(2-Chloro-6-fluorobenzene)acrylic acid chloride; 2-Propenoyl chloride, 3-(2-chloro-6-fluorophenyl)-, (2E)-
EINECS	Contact for details

Quality Control

Our (2E)-3-(2-Chloro-6-Fluorophenyl)Acryloyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in cGMP (Current Good Manufacturing Practice) environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and moisture-sensitive (hygroscopic) compound, it must be kept under an inert atmosphere (argon or nitrogen) and protected from moisture. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.