Description

2-(5-Chloro-2-Thienyl)-7,8-Dimethylquinoline-4-Carbonyl Chloride is a high-value, multifunctional heterocyclic building block and key synthetic intermediate. Its core value lies in its reactive acid chloride group and complex quinoline-thiophene hybrid structure, enabling the precise construction of advanced molecular architectures. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics targeting complex biological pathways.
• Agrochemical Research: Serves as a key building block for developing novel pesticides, herbicides, and fungicides with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of organic semiconductors, luminescent materials, and metal-organic frameworks (MOFs) due to its electron-rich, conjugated system.
• Chemical Biology & Proteomics: Employed as a coupling agent or linker for labeling biomolecules, developing chemical probes, and activity-based protein profiling (ABPP).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, patent-protected molecules for clients.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental studies in organic synthesis, catalysis, and the exploration of new chemical space.

Basic Information

Product Name	2-(5-Chloro-2-Thienyl)-7,8-Dimethylquinoline-4-Carbonyl Chloride
CAS No.	1160261-41-5
Molecular Formula	C16H11Cl2NOS
Molecular Weight	336.23 g/mol
Synonyms	7,8-Dimethyl-2-(5-chloro-2-thienyl)quinoline-4-carbonyl chloride; 2-(5-Chlorothiophen-2-yl)-7,8-dimethylquinoline-4-carbonyl chloride; 4-Quinolinecarbonyl chloride, 2-(5-chloro-2-thienyl)-7,8-dimethyl-; 1160261-41-5; CTDQ Carbonyl Chloride; 5-Chloro-2-thienyl quinoline carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Chloro-2-Thienyl)-7,8-Dimethylquinoline-4-Carbonyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for advanced pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee specification adherence and support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.