Description

3-{[3-(Trifluoromethyl)Benzyl]Oxy}Benzoyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive benzoyl chloride functional group and trifluoromethyl-benzyl ether moiety. This compound matters as a critical building block for synthesizing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals where the trifluoromethyl group enhances metabolic stability and lipophilicity. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce this specific aromatic ether-acid chloride fragment into their target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the bioactivity of the trifluoromethyl aromatic system.
• Liquid Crystal & OLED Materials: Serves as a building block for creating specialized aromatic cores in electronic and display materials.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for synthesizing high-performance polymers with specific thermal and chemical resistance.
• Chemical Research & Development: A versatile reagent for academic and industrial research focused on medicinal chemistry and material science.
• Peptide & Protein Modification: Utilized for acylation reactions to modify biomolecules, introducing the lipophilic trifluoromethylbenzyloxy group.

Basic Information

Product Name	3-{[3-(Trifluoromethyl)Benzyl]Oxy}Benzoyl Chloride
CAS No.	1160260-72-9
Molecular Formula	C15H10ClF3O2
Molecular Weight	314.69 g/mol
Synonyms	3-[(3-(Trifluoromethyl)benzyl)oxy]benzoyl chloride; 3-((3-(Trifluoromethyl)benzyl)oxy)benzoic acid chloride; m-[(α,α,α-Trifluoro-m-tolyl)methoxy]benzoyl chloride; 3-{[3-(Trifluoromethyl)phenyl]methoxy}benzoyl chloride; 3-(3-Trifluoromethylbenzyloxy)benzoyl chloride; Benzoyl chloride, 3-[[3-(trifluoromethyl)phenyl]methoxy]-; 1160260-72-9
EINECS	Contact for details

Quality Control

Our 3-{[3-(Trifluoromethyl)Benzyl]Oxy}Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical characteristics. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical B2B and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and must be protected from moisture. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.