Description

4-[(2-Chloro-6-Fluorobenzyl)Oxy]-3-Methoxybenzoyl Chloride is a high-purity, reactive benzoyl chloride derivative used as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its bifunctional reactivity, where the acid chloride group enables efficient amide or ester bond formation, and the substituted benzyloxy moiety provides a versatile handle for further structural elaboration. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for constructing complex molecules in drug discovery and active ingredient synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging its halogenated aromatic structure.
• Chemical Research & Development: Serves as a versatile precursor in medicinal chemistry for creating compound libraries and exploring structure-activity relationships (SAR).
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development and scale-up projects.
• Material Science Precursor: Potential use in synthesizing specialized monomers or ligands for advanced polymeric or coordination complex materials.

Basic Information

Product Name	4-[(2-Chloro-6-Fluorobenzyl)Oxy]-3-Methoxybenzoyl Chloride
CAS No.	1160260-59-2
Molecular Formula	C16H13Cl2FO3
Molecular Weight	343.18 g/mol
Synonyms	3-Methoxy-4-[(2-chloro-6-fluorobenzyl)oxy]benzoyl chloride; 4-[(2-Chloro-6-fluorophenyl)methoxy]-3-methoxybenzoyl chloride; Benzoyl chloride, 4-[(2-chloro-6-fluorobenzyl)oxy]-3-methoxy-; 2-Chloro-6-fluorobenzyl 3-methoxy-4-chlorocarbonylphenyl ether; Vanillic acid chloride, 4-[(2-chloro-6-fluorobenzyl)oxy] derivative
EINECS	Contact for details

Quality Control

Our production of 4-[(2-Chloro-6-Fluorobenzyl)Oxy]-3-Methoxybenzoyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and acid chloride nature, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.