Description

4-[(2-Chloro-6-Fluorobenzyl)Oxy]-3-Ethoxybenzoyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive acid chloride functional group. This compound is of critical importance for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted small-molecule therapeutics. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and agrochemical industries seeking to build sophisticated molecular architectures.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the preparation of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Active Ingredient Development: Used in the research and production of advanced herbicides and pesticides, leveraging its halogenated benzyloxy and ethoxy motifs.
• Peptide Coupling Reagent: Functions as an efficient coupling agent in peptide synthesis due to its highly reactive benzoyl chloride moiety.
• Material Science Research: Employed in the synthesis of specialized polymers and liquid crystals where specific aromatic ether linkages are required.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom chemical synthesis projects.

Basic Information

Item	Detail
Product Name	4-[(2-Chloro-6-Fluorobenzyl)Oxy]-3-Ethoxybenzoyl Chloride
CAS No.	1160260-52-5
Molecular Formula	C₁₇H₁₅Cl₂FO₃
Molecular Weight	357.21 g/mol
Synonyms	3-Ethoxy-4-[(2-chloro-6-fluorobenzyl)oxy]benzoyl chloride; 4-[(2-Chloro-6-fluorophenyl)methoxy]-3-ethoxybenzoyl chloride; 2-Chloro-6-fluorobenzyl 3-ethoxy-4-(chlorocarbonyl)phenyl ether; Benzoyl chloride, 4-[(2-chloro-6-fluorobenzyl)oxy]-3-ethoxy-; 1160260-52-5
EINECS	Contact for details

Quality Control

Our production of 4-[(2-Chloro-6-Fluorobenzyl)Oxy]-3-Ethoxybenzoyl Chloride adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. The material is manufactured under GMP-like conditions suitable for pharmaceutical intermediate applications. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.