Description

2-(2,4-Difluorophenoxy)Butanoyl Chloride is a specialized organic intermediate featuring a reactive acid chloride group and a difluorophenoxy moiety. This compound matters as a critical building block for synthesizing more complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in fine chemical and active pharmaceutical ingredient (API) manufacturing for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology drugs where fluorinated compounds are prevalent.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Polymer Modification Agent: Employed to introduce fluorinated phenoxy side chains into polymers, altering their surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: Utilized in academic and industrial laboratories for acylations and the construction of complex ether and ester linkages under mild conditions.
• Fluorinated Surfactant Research: Acts as an intermediate in the development of novel fluorosurfactants with unique wetting and leveling properties.

Basic Information

Product Name	2-(2,4-Difluorophenoxy)Butanoyl Chloride
CAS No.	1160257-44-2
Molecular Formula	C₁₀H₉ClF₂O₂
Molecular Weight	234.63 g/mol
Synonyms	2-(2,4-Difluorophenoxy)butyryl chloride; Butanoyl chloride, 2-(2,4-difluorophenoxy)-; α-(2,4-Difluorophenoxy)butyryl chloride; 2-(2,4-Difluorophenoxy)butanoic acid chloride; 2,4-DFPBC; 2-(2,4-Difluorophenoxy)butyric acid chloride
EINECS	Contact for details

Quality Control

Our 2-(2,4-Difluorophenoxy)Butanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.