Description

8-Chloro-2-(5-Methyl-2-Thienyl)Quinoline-4-Carbonyl Chloride is a high-value, multi-functional organic intermediate characterized by its reactive carbonyl chloride and halogenated quinoline-thiophene hybrid structure. This compound matters for its critical role as a versatile building block in advanced synthetic chemistry, enabling the construction of complex molecules with potential biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, or oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging the bioactivity of the quinoline and thiophene motifs.
• Material Science: Acts as a monomer or functionalizing agent in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) or semiconductors.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling or modifying biomolecules (proteins, nucleic acids) in probe development and biochemical assays.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in heterocyclic and cross-coupling chemistry.
• Ligand Synthesis: Provides a scaffold for constructing complex chelating ligands used in catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	8-Chloro-2-(5-Methyl-2-Thienyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160256-80-3
Molecular Formula	C16H9Cl2NOS
Molecular Weight	334.22 g/mol
Synonyms	8-Chloro-2-(5-methylthiophen-2-yl)quinoline-4-carbonyl chloride; 2-(5-Methyl-2-thienyl)-8-chloro-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 8-chloro-2-(5-methyl-2-thienyl)-; 1160256-80-3; 8-Chloro-2-(5-methyl-2-thienyl)quinoline-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-(5-Methyl-2-Thienyl)Quinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications. We support cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.