Description

8-Chloro-2-(4-Isobutylphenyl)Quinoline-4-Carbonyl Chloride is a high-purity, bifunctional organic intermediate of significant importance in advanced pharmaceutical synthesis. Its molecular structure, featuring both a reactive acid chloride group and a halogenated quinoline core, makes it a versatile building block for constructing complex active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, particularly for anti-inflammatory and antiviral applications.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Utilized in the creation of fluorescent tags or molecular probes for biochemical and diagnostic research due to the quinoline scaffold.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes to introduce the 2-arylquinoline moiety into more complex molecular architectures.

Basic Information

Item	Detail
Product Name	8-Chloro-2-(4-Isobutylphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160256-33-6
Molecular Formula	C20H17Cl2NO
Molecular Weight	358.26 g/mol
Synonyms	8-Chloro-2-(4-isobutylphenyl)quinoline-4-carbonyl chloride; 2-(4-Isobutylphenyl)-8-chloroquinoline-4-carbonyl chloride; 8-Chloro-2-[4-(2-methylpropyl)phenyl]quinoline-4-carbonyl chloride; Quinoline-4-carbonyl chloride, 8-chloro-2-[4-(2-methylpropyl)phenyl]-; CAS 1160256-33-6
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-(4-Isobutylphenyl)Quinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.