Description

8-Chloro-2-(3-Isobutoxyphenyl)Quinoline-4-Carbonyl Chloride is a high-purity, reactive chemical intermediate of significant importance in advanced organic synthesis. Its core value lies in its bifunctional nature, featuring both a reactive acid chloride group and a halogenated quinoline scaffold, making it a versatile building block for constructing complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting kinase inhibition or other quinoline-based therapeutic pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or pesticides where the quinoline moiety can impart specific biological activity.
• Material Science: Serves as a monomer or functionalizing agent for creating advanced polymers, liquid crystals, or organic electronic materials with tailored properties.
• Chemical Synthesis: Employed in medicinal and combinatorial chemistry for the efficient construction of complex heterocyclic libraries via amide bond formation or further functionalization.
• Dye & Pigment Precursor: Acts as a building block for synthesizing specialized quinoline-based dyes and colorants.

Basic Information

Product Name	8-Chloro-2-(3-Isobutoxyphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160255-98-0
Molecular Formula	C21H17Cl2NO2
Molecular Weight	386.27 g/mol
Synonyms	8-Chloro-2-(3-isobutoxyphenyl)quinoline-4-carbonyl chloride; 2-(3-Isobutoxyphenyl)-8-chloroquinoline-4-carbonyl chloride; 4-Quinolinecarbonyl chloride, 8-chloro-2-[3-(2-methylpropoxy)phenyl]-; 8-Chloro-2-(3-isobutoxy-phenyl)-quinoline-4-carbonyl chloride; 1160255-98-0
EINECS	Contact for details

Quality Control

Our 8-Chloro-2-(3-Isobutoxyphenyl)Quinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.