Description

7-Chloro-2-(4-Isobutoxyphenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride functional group. This compound is critical for the synthesis of complex molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting the production of novel active pharmaceutical ingredients (APIs) and other biologically active quinoline derivatives.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases or oncology.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex organic molecules requiring the quinoline scaffold.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	7-Chloro-2-(4-Isobutoxyphenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160255-92-4
Molecular Formula	C22H19Cl2NO2
Molecular Weight	400.30 g/mol
Synonyms	7-Chloro-2-(4-isobutoxyphenyl)-8-methylquinoline-4-carbonyl chloride; 4-Quinolinecarbonyl chloride, 7-chloro-2-[4-(2-methylpropoxy)phenyl]-8-methyl-; 2-(4-Isobutoxyphenyl)-7-chloro-8-methyl-4-quinolinecarbonyl chloride; 7-Chloro-8-methyl-2-(4-isobutoxyphenyl)quinoline-4-carbonyl chloride; CAS 1160255-92-4
EINECS	Contact for details

Quality Control

Our production of 7-Chloro-2-(4-Isobutoxyphenyl)-8-Methylquinoline-4-Carbonyl Chloride adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to supplying material that meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.