Description

2-(3-Bromophenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride functional group. This compound is critical for the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutic agents, especially those targeting specific enzyme pathways where the quinoline scaffold is active.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing a quinoline core structure.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new compounds with potential biological activity.
• Chemical Synthesis: Serves as a versatile reagent for introducing the 2-(3-bromophenyl)-8-methylquinoline moiety into larger molecular frameworks via amide or ester bond formation.
• Agrochemical Development: Potential use in the research and synthesis of novel agrochemicals and pesticides that leverage heterocyclic chemistry.
• Material Science Precursor: Can be employed in the development of organic electronic materials or metal-organic frameworks (MOFs) due to its aromatic and halogenated structure.

Basic Information

Product Name	2-(3-Bromophenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160254-35-2
Molecular Formula	C18H11BrClNO
Molecular Weight	372.65 g/mol
Synonyms	8-Methyl-2-(3-bromophenyl)quinoline-4-carbonyl chloride; 2-(3-Bromophenyl)-8-methyl-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 2-(3-bromophenyl)-8-methyl-; 1160254-35-2
EINECS	Contact for details

Quality Control

Our 2-(3-Bromophenyl)-8-Methylquinoline-4-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.