Description

2-(4-tert-Butylphenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-value, reactive chemical intermediate characterized by its quinoline-based structure and acid chloride functionality. This compound is critical for facilitating efficient amide bond formation and other nucleophilic substitution reactions in advanced synthetic workflows. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and complex organic molecules.

Application

• Key building block in the pharmaceutical synthesis of potential drug candidates, particularly those targeting central nervous system and oncological pathways.
• Intermediate for the development of advanced agrochemicals, including herbicides and fungicides with novel modes of action.
• Precursor in materials science for the creation of functionalized organic ligands and coordination complexes.
• Used in academic and industrial R&D for exploring new chemical entities and reaction methodologies.
• Starting material for the synthesis of fluorescent dyes and markers due to the quinoline chromophore.
• Intermediate in the production of specialty fine chemicals and custom synthesis projects.

Basic Information

Product Name	2-(4-tert-Butylphenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160254-27-2
Molecular Formula	C21H20ClNO
Molecular Weight	337.84 g/mol
Synonyms	8-Methyl-2-[4-(1,1-dimethylethyl)phenyl]-4-quinolinecarbonyl chloride; 2-(4-tert-Butylphenyl)-8-methyl-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 2-[4-(1,1-dimethylethyl)phenyl]-8-methyl-; 1160254-27-2; 2-(4-tert-butylphenyl)-8-methylquinoline-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2-(4-tert-Butylphenyl)-8-Methylquinoline-4-Carbonyl Chloride adheres to stringent in-process controls and final batch analysis to ensure consistent high purity and reactivity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We are committed to meeting the exacting standards required for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.