Description

4-[(2-Chloro-4-Fluorobenzyl)Oxy]-3-Ethoxybenzoyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive acid chloride functional group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of new drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides and pesticides, leveraging its halogenated benzyloxy and ethoxy motifs.
• Peptide Coupling Reagent: The reactive benzoyl chloride moiety can be employed in peptide synthesis and other amide bond formation reactions.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialized polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	4-[(2-Chloro-4-Fluorobenzyl)Oxy]-3-Ethoxybenzoyl Chloride
CAS No.	1160251-09-1
Molecular Formula	C₁₇H₁₅Cl₂FO₃
Molecular Weight	373.21 g/mol
Synonyms	3-Ethoxy-4-[(2-chloro-4-fluorobenzyl)oxy]benzoyl chloride; 4-(2-Chloro-4-fluorobenzyloxy)-3-ethoxybenzoyl chloride; Benzoyl chloride, 4-[(2-chloro-4-fluorobenzyl)oxy]-3-ethoxy-; 1160251-09-1; AKOS025247315; F2198-6475; 4-[(2-Chloro-4-fluorobenzyl)oxy]-3-ethoxybenzoic acid chloride
EINECS	Contact for details

Quality Control

Our production of 4-[(2-Chloro-4-Fluorobenzyl)Oxy]-3-Ethoxybenzoyl Chloride adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against established analytical methods, including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.