Description

tert-Butyl Hexahydro-1H-Pyrrolo[3,2-C]Pyridine-5(6H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected heterocyclic amines. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile nitrogen-containing scaffold for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the fields of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Synthesis: Used in the construction of molecules targeting various protease enzymes, relevant for antiviral and anticancer therapies.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl Hexahydro-1H-Pyrrolo[3,2-C]Pyridine-5(6H)-Carboxylate
CAS No.	1160247-99-3
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl 1,2,3,3a,4,6a-Hexahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate; 5-Boc-1,2,3,3a,4,6a-Hexahydro-1H-pyrrolo[3,2-c]pyridine; 1,2,3,3a,4,6a-Hexahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester; tert-Butyl 1,2,3,3a,4,6a-hexahydropyrrolo[3,2-c]pyridine-5-carboxylate; Boc-Protected Hexahydropyrrolopyridine; 5-(tert-Butoxycarbonyl)-1,2,3,3a,4,6a-hexahydro-1H-pyrrolo[3,2-c]pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl Hexahydro-1H-Pyrrolo[3,2-C]Pyridine-5(6H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.