Description

(Z)-5-((5-Fluoro-2-Oxoindolin-3-Ylidene)Methyl)-2,4-Dimethyl-1H-Pyrrole-3-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride group and complex heterocyclic structure. This compound is of significant commercial importance for the synthesis of targeted, bioactive molecules, particularly in oncology research. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel kinase inhibitors and other small-molecule therapeutics.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a critical building block for the development of novel drug candidates, particularly in oncology.
• Kinase Inhibitor Precursor: Used in the research and production of targeted therapies that inhibit specific protein kinases involved in cancer cell proliferation.
• Fluorinated Compound Research: The presence of the fluorine atom makes it valuable for creating compounds with enhanced metabolic stability and membrane permeability in medicinal chemistry.
• Organic Light-Emitting Diode (OLED) Materials: Potential use in the development of specialized organic electronic materials due to its conjugated molecular framework.
• Agrochemical Intermediate: Can be utilized in the synthesis of advanced, high-performance active ingredients for crop protection.
• Dye and Pigment Chemistry: The indolinone and pyrrole core structures are relevant for synthesizing specialized dyes and functional pigments.

Basic Information

Product Name	(Z)-5-((5-Fluoro-2-Oxoindolin-3-Ylidene)Methyl)-2,4-Dimethyl-1H-Pyrrole-3-Carbonyl Chloride
CAS No.	1158560-66-7
Molecular Formula	C₁₇H₁₄ClFN₂O₂
Molecular Weight	332.76 g/mol
Synonyms	5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbonyl chloride; 1H-Pyrrole-3-carbonyl chloride, 5-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-; (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carbonyl chloride; 1158560-66-7; 5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carbonyl chloride (Z-isomer)
EINECS	Contact for details

Quality Control

Our (Z)-5-((5-Fluoro-2-Oxoindolin-3-Ylidene)Methyl)-2,4-Dimethyl-1H-Pyrrole-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (Z-Isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.