Description

2'-Deoxy-2',2'-Difluorocytidine 5'-(4-Methylbenzenesulfonate) is a high-purity nucleoside derivative and a critical pharmaceutical intermediate. This compound is essential for the synthesis of advanced antiviral and anticancer agents, where its precise chemical structure is paramount for efficacy. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of nucleoside analog therapeutics, including those targeting viral infections and oncology.

Application

• Key Intermediate in Antiviral Drug Synthesis: A vital building block for the production of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Oncology Research & Drug Development: Used in the synthesis of chemotherapeutic agents that act as antimetabolites to disrupt cancer cell DNA/RNA synthesis.
• Biochemical Research: Serves as a modified nucleoside substrate for enzymatic studies, polymerase research, and probing nucleic acid interactions.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Used as an analytical standard in quality control (QC) and quality assurance (QA) laboratories for method development and validation.

Basic Information

Product Name	2'-Deoxy-2',2'-Difluorocytidine 5'-(4-Methylbenzenesulfonate)
CAS No.	1151528-53-8
Molecular Formula	C17H19F2N3O7S
Molecular Weight	447.41 g/mol
Synonyms	Gemcitabine 5'-Tosylate; 2'-Deoxy-2',2'-difluorocytidine 5'-tosylate; 2',2'-Difluorodeoxycytidine 5'-(p-toluenesulfonate); dFdC 5'-Tosylate; 5'-O-Tosylgemcitabine; 4-Methylbenzenesulfonic Acid 2'-Deoxy-2',2'-difluorocytidin-5'-yl Ester; Gemcitabine Tosylate; Gemcitabine 5'-O-(4-methylbenzenesulfonate)
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2',2'-Difluorocytidine 5'-(4-Methylbenzenesulfonate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.