Description

2'-Deoxy-5'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-2',2'-Difluorocytidine CAS NO 1151528-36-7 is a key nucleoside intermediate, specifically a silyl-protected difluorocytidine derivative, essential for the synthesis of complex antiviral and anticancer therapeutics. Its primary value lies in its role as a critical building block in the production of sophisticated active pharmaceutical ingredients (APIs), enabling precise molecular modifications. This high-purity intermediate is indispensable for pharmaceutical R&D laboratories and manufacturers focused on nucleoside analog drugs, particularly those targeting viral infections and oncology.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel nucleoside-based antiviral and anticancer agents.
• Antiviral Drug Development: Used in research and production of therapeutics targeting viruses such as hepatitis C (HCV) and other RNA viruses.
• Oncology Research: Serves as a building block for developing cytostatic and chemotherapeutic nucleoside analogs.
• Prodrug Synthesis: Employed in creating prodrug forms of nucleoside analogs to enhance bioavailability and targeting.
• Process Chemistry & Scale-up: Utilized in optimizing synthetic routes from laboratory scale to commercial manufacturing.
• Biochemical Research: Acts as a modified nucleoside substrate for studying enzyme mechanisms and metabolic pathways.

Basic Information

Item	Details
Product Name	2'-Deoxy-5'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-2',2'-Difluorocytidine
CAS No.	1151528-36-7
Molecular Formula	C16H27F2N3O4Si
Molecular Weight	391.50 g/mol
Synonyms	2'-Deoxy-2',2'-difluoro-5'-O-[(1,1-dimethylethyl)dimethylsilyl]cytidine; 5'-O-(tert-Butyldimethylsilyl)-2'-deoxy-2',2'-difluorocytidine; 5'-O-TBDMS-2'-deoxy-2',2'-difluorocytidine; TBDMS-2'-F-2'-dCyd; 2'-Deoxy-2',2'-difluorocytidine 5'-O-TBDMS ether; tert-Butyldimethylsilyl 2'-deoxy-2',2'-difluorocytidin-5'-yl ether; 1-[(2R,3R,4R,5R)-3-Fluoro-4-fluoro-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]tetrahydrofuran-2-yl]-4-aminopyrimidin-2-one
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and purity essential for pharmaceutical synthesis. Our quality control protocols include comprehensive analytical testing via HPLC, NMR, and mass spectrometry to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each batch, documenting compliance with agreed specifications. We support audits and can provide materials suitable for use under cGMP (Current Good Manufacturing Practice) guidelines for advanced pharmaceutical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.