Description

4'-C-Azido-3'-Deoxy-3'-Fluorocytidine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. Its unique structure, incorporating both azido and fluoro substituents, makes it a valuable building block for probing biological mechanisms and developing novel therapeutic agents. This compound is primarily utilized by researchers and developers in the fields of antiviral drug discovery, oligonucleotide synthesis, and medicinal chemistry.

Application

• Antiviral Nucleoside Analogue Research: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the development of novel antiviral therapies.
• Oligonucleotide Synthesis: Used as a modified monomer in the synthesis of antisense oligonucleotides and siRNAs to enhance stability and biological activity.
• Medicinal Chemistry & Lead Optimization: Employed as a versatile scaffold for structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Biochemical Probes: Functions as a tool compound for studying enzyme mechanisms, particularly those involving nucleoside kinases and polymerases.
• Click Chemistry Substrates: The azido group enables its use in bioorthogonal conjugation reactions (e.g., CuAAC) for labeling and bioconjugation applications.
• Radiopharmaceutical Precursor: Potential use as a precursor for the synthesis of fluorinated tracers in Positron Emission Tomography (PET) imaging.

Basic Information

Product Name	4'-C-Azido-3'-Deoxy-3'-Fluorocytidine
CAS No.	1145869-46-0
Molecular Formula	C9H11FN6O4
Molecular Weight	286.22 g/mol
Synonyms	3'-Deoxy-3'-fluoro-4'-C-azidocytidine; 4'-Azido-3'-deoxy-3'-fluorocytidine; 1-(4-Azido-3-fluoro-3,4-dideoxy-β-D-erythro-pentofuranosyl)cytosine; 4'-C-Azido-3'-F-cytidine; 4'-Azido-3'-fluoro-2',3'-dideoxycytidine; 3'-Fluoro-4'-azido-2',3'-dideoxycytidine
EINECS	Contact for details

Quality Control

Our 4'-C-Azido-3'-Deoxy-3'-Fluorocytidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.