Description

4'-Azido-3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine is a sophisticated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is a key synthetic intermediate, valued for its unique chemical structure that enables the precise modification of nucleic acid sequences. It is primarily utilized by research scientists and process chemists in the pharmaceutical and biotechnology sectors. The material is essential for developing novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of modified nucleoside analogs and oligonucleotides.
• Antiviral Drug Development: Used in research programs targeting the creation of new antiviral medications, including potential treatments for hepatitis and other viral infections.
• Anticancer Agent Synthesis: Serves as a precursor in the development of nucleoside-based chemotherapeutic agents.
• Oligonucleotide Synthesis: Key monomer for introducing specific modifications into synthetic DNA/RNA strands for research and therapeutic applications (e.g., antisense oligonucleotides).
• Proteomics & Genomics Research: Employed as a chemical probe or labeled precursor in biochemical studies to investigate cellular processes.
• Process Chemistry & Scale-Up: Supplied for route development and optimization in pilot-scale and commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4'-Azido-3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine
CAS No.	1145869-37-9
Molecular Formula	C24H18FN5O7
Molecular Weight	507.43 g/mol
Synonyms	2'-Deoxy-2'-fluoro-4'-azido-3',5'-di-O-benzoyl-β-D-arabinouridine; 4'-Azido-2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinouridine; 1-[(2R,3S,4R,5R)-4-Azido-5-(benzoyloxymethyl)-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione 3,5-dibenzoate; 2'-Fluoro-4'-azido-3',5'-di-O-benzoyl-arabinouridine; 4'-N3-2'-F-araU(Bz)2; Arabinouridine, 4'-azido-3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-, β-D-
EINECS	Contact for details

Quality Control

Our 4'-Azido-3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.