Description

4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-7-Ethoxy-6-[(1-Methyl-2-Pyrrolidinylidene)Amino]-3-Quinolinecarbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for its role as a key synthetic precursor. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents. The material is supplied to meet the stringent quality requirements of the life sciences industry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of targeted small-molecule drug candidates.
• Kinase Inhibitor Research: Used in the discovery and development of potent and selective kinase inhibitors for oncology and other therapeutic areas.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Development: Supplied for scale-up synthesis to produce material for pharmacological and toxicological evaluation.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-7-Ethoxy-6-[(1-Methyl-2-Pyrrolidinylidene)Amino]-3-Quinolinecarbonitrile
CAS No.	1144516-21-1
Molecular Formula	C29H26ClN7O2
Molecular Weight	540.02 g/mol
Synonyms	7-Ethoxy-4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-6-[(1-methyl-2-pyrrolidinylidene)amino]-3-quinolinecarbonitrile; 4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-((1-methylpyrrolidin-2-ylidene)amino)quinoline-3-carbonitrile; UNII-5V8C6599J6; 5V8C6599J6; BDBM50190087; CHEMBL3186662; AKOS025147065; A-674563 (related analog)
EINECS	Contact for details

Quality Control

Every batch of 4-[[3-Chloro-4-(2-Pyridinylmethoxy)Phenyl]Amino]-7-Ethoxy-6-[(1-Methyl-2-Pyrrolidinylidene)Amino]-3-Quinolinecarbonitrile is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to support cGMP-compliant applications in pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.