Description

Bromo-Peg1-Azide CAS NO 1144106-65-9 is a bifunctional polyethylene glycol (PEG) linker featuring a reactive bromo group and an azide moiety, enabling orthogonal conjugation strategies in bioconjugation and materials science. This compound is essential for creating stable, well-defined molecular architectures, particularly in the development of antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced polymer synthesis who require reliable, high-purity building blocks for click chemistry and spacer arm introduction.

Application

• Bioconjugation and ADC Development: Serves as a heterobifunctional crosslinker for attaching cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via copper-free or copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptide and Protein Modification: Used to introduce PEG spacers (PEGylation) or functional handles onto biomolecules to enhance solubility, stability, and pharmacokinetic properties.
• Materials Science and Surface Functionalization: Enables the grafting of azide-terminated polymers or molecules onto bromo-functionalized surfaces, nanoparticles, or other substrates for creating bioactive interfaces.
• Polymer Chemistry: Acts as a monomer or initiator in controlled polymerization techniques (e.g., ATRP using the bromo group) to synthesize azide-terminated polymers with precise architectures.
• Chemical Probe Synthesis: A key intermediate for constructing activity-based probes, diagnostic agents, and imaging tools used in chemical biology and drug discovery.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries through sequential or parallel conjugation reactions in medicinal chemistry.

Basic Information

Product Name	Bromo-Peg1-Azide
CAS No.	1144106-65-9
Molecular Formula	C5H10BrN3O
Molecular Weight	208.06 g/mol
Synonyms	1-Azido-2-(2-bromoethoxy)ethane; 2-(2-Azidoethoxy)ethyl bromide; Bromo-PEG1-azide; Bromo-ethyleneglycol-azide; Azido-PEG1-bromide; Br-PEG1-N3; N3-PEG1-Br; 2-Bromoethyl 2-azidoethyl ether
EINECS	Contact for details

Quality Control

Our Bromo-Peg1-Azide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and commercial applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards, and specifications can be tailored to meet specific project requirements, including cGMP for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. The product is light-sensitive and should be handled under inert atmosphere when appropriate to maximize shelf life. Keep away from strong oxidizing agents and sources of heat.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.