Description

Azd5363 CAS NO 1143532-39-1 is a potent and selective small molecule inhibitor of the protein kinase AKT (also known as Protein Kinase B). This compound is a critical research tool for investigating the PI3K/AKT/mTOR signaling pathway, which plays a central role in cell growth, proliferation, and survival. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in oncology and metabolic disease research for target validation, mechanism-of-action studies, and preclinical development.

Application

• Biochemical Research: Used as a selective AKT inhibitor to study the role of the PI3K/AKT pathway in cellular signaling and disease models.
• Oncology Research: A key tool for investigating tumor cell proliferation, survival, and resistance mechanisms in various cancer cell lines.
• Preclinical Drug Development: Serves as a reference compound or a starting point for the development of novel therapeutic agents targeting AKT.
• Mechanistic Studies: Employed to elucidate the downstream effects of AKT inhibition on apoptosis, metabolism, and gene expression.
• High-Throughput Screening (HTS): Used as a control or standard in assay development and screening campaigns for AKT inhibitors.
• Academic Research: Facilitates fundamental biological research in universities and institutes focused on cell biology and signal transduction.

Basic Information

Product Name	Azd5363
CAS No.	1143532-39-1
Molecular Formula	C₂₁H₂₃N₇O₂
Molecular Weight	405.46 g/mol
Synonyms	Capivasertib; AZD-5363; AZD 5363; 4-[4-(1-Aminocyclobutyl)phenyl]-3-(4-cyanophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine; 4-[4-(1-Aminocyclobutyl)phenyl]-3-(4-cyanophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine; AKT Inhibitor AZD5363
EINECS	Contact for details

Quality Control

Our Azd5363 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous in-house specifications. We support research and development with materials suitable for preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.