Description

Methyl 6-Chloro-5-Pivalamidopicolinate CAS NO 1142191-95-4 is a high-purity, advanced pharmaceutical intermediate characterized by its specific picolinate ester and pivalamide functional groups. This compound is of critical importance in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutic agents.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of sophisticated small-molecule drugs.
• Neurological Drug Research: Used in the R&D of compounds targeting central nervous system disorders.
• Metabolic Disease Therapeutics: Employed in the development of potential treatments for diabetes and related metabolic conditions.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes from laboratory to commercial manufacturing scale.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for client-specific projects.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	Methyl 6-Chloro-5-Pivalamidopicolinate
CAS No.	1142191-95-4
Molecular Formula	C12H15ClN2O3
Molecular Weight	270.71 g/mol
Synonyms	Methyl 6-chloro-5-(2,2-dimethylpropanamido)picolinate; 5-Pivalamido-6-chloropicolinic acid methyl ester; 6-Chloro-5-(pivalamido)picolinic acid methyl ester; Methyl 5-(pivalamido)-6-chloropicolinate; 2-Pyridinecarboxylic acid, 6-chloro-5-[(2,2-dimethyl-1-oxopropyl)amino]-, methyl ester; Picolinate intermediate 1142191-95-4
EINECS	Contact for details

Quality Control

Our Methyl 6-Chloro-5-Pivalamidopicolinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting all specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.