Description

Cabozantinib Malate is a high-purity small molecule inhibitor targeting multiple receptor tyrosine kinases, including MET, VEGFR2, and RET. Its primary commercial value lies in its critical role as the active pharmaceutical ingredient (API) in targeted cancer therapies, offering significant efficacy in treating advanced renal cell carcinoma and hepatocellular carcinoma. This compound is essential for pharmaceutical manufacturers engaged in the development and production of innovative oncology drugs, as well as for research institutions conducting preclinical studies on tyrosine kinase signaling pathways.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulated anti-cancer medications such as Cabometyx® and Cometriq®.
• Oncology Research: A key reference standard and tool compound for in vitro and in vivo studies on MET, VEGFR, and AXL signaling pathways.
• Drug Development: Serves as a critical intermediate in the synthesis and process development of novel tyrosine kinase inhibitor (TKI) therapies.
• Clinical Trial Materials: Supplied under cGMP conditions for use in manufacturing clinical trial supplies for investigational new drugs (INDs).
• Biochemical Assays: Used in high-throughput screening (HTS) and enzyme inhibition assays to study kinase activity and drug resistance mechanisms.

Basic Information

Product Name	Cabozantinib Malate
CAS No.	1140909-48-3
Molecular Formula	C₂₈H₂₄FN₃O₅ • C₄H₆O₅
Molecular Weight	635.59 g/mol
Synonyms	Cabozantinib S-malate; XL184 malate; BMS-907351 malate; N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate; Cometriq (brand name salt form); Cabometyx (brand name salt form)
EINECS	Contact for details

Quality Control

Our Cabozantinib Malate is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH Q7 guidelines and can supply material suitable for use under cGMP conditions for advanced pharmaceutical applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.