Description

1-Chloro-2-(Difluoromethoxy)-3-Fluorobenzene, 97% is a high-purity, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. This compound is valued for its unique difluoromethoxy and halogen substituents, which are critical for modulating the electronic and steric properties of target molecules. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex fluorinated aryl groups.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new reaction methodologies and creating specialized chemical libraries.

Basic Information

Product Name	1-Chloro-2-(Difluoromethoxy)-3-Fluorobenzene, 97%
CAS No.	1136961-91-5
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	1-Chloro-2-(difluoromethoxy)-3-fluorobenzene; 3-Fluoro-2-(difluoromethoxy)chlorobenzene; 2-(Difluoromethoxy)-1-chloro-3-fluorobenzene; Benzene, 1-chloro-2-(difluoromethoxy)-3-fluoro-; 1-Chloro-3-fluoro-2-(difluoromethoxy)benzene; Difluoromethoxy-chloro-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(Difluoromethoxy)-3-Fluorobenzene, 97% is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency meet the specified standards. A detailed Certificate of Analysis (COA) with lot-specific data is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed and stored upright away from heat sources and incompatible materials such as strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.