Description

Exherin (Trifluoroacetate) is a high-purity, peptide-derived molecular probe designed for selective inhibition of epithelial cadherin (E-cadherin) interactions in controlled research environments. It serves as a critical tool for studying cell adhesion mechanisms, epithelial-mesenchymal transition (EMT), and metastatic pathways in preclinical oncology and developmental biology research. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in target validation, assay development, and mechanistic pharmacology studies.

Application

• Target validation studies for E-cadherin–mediated signaling pathways in solid tumor models
• In vitro and in vivo assessment of epithelial-mesenchymal transition (EMT) modulation
• Development of functional cell-based assays for cadherin-dependent adhesion and migration
• Supporting preclinical pharmacology programs in anti-metastatic drug discovery
• Use as a reference standard in analytical method development (HPLC, LC-MS)
• Structural and biophysical studies of cadherin extracellular domain binding kinetics
• Controlled differentiation protocols in stem cell and organoid culture systems
• Investigation of barrier function integrity in endothelial and epithelial monolayer models

Basic Information

Product Name	Exherin (Trifluoroacetate)
CAS No.	1135237-88-5
Molecular Formula	C24H36F3N5O8
Molecular Weight	595.57 g/mol
Synonyms	Exherin TFA; Exherin trifluoroacetate salt; N-(4-{[(2S)-2-Amino-3-methylbutanoyl]amino}benzoyl)-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-threonyl-L-leucyl-L-phenylalanyl-L-prolyl-L-valyl-L-arginylamide trifluoroacetate; E-cadherin inhibitory peptide (TFA salt); Cadherin antagonist peptide TFA; Exherin acetate (note: acetate form is distinct—this is TFA); CAS 1135237-88-5; Peptide inhibitor of E-cadherin homophilic binding
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Exherin (Trifluoroacetate) are verified for identity (HPLC retention time, mass spectrometry), purity (≥95.0% by HPLC), peptide content (UV absorbance at 214 nm), residual solvents (GC), and endotoxin levels (<1.0 EU/mg). Testing adheres to ICH Q5, Q6A, and USP Chapter <1058> Analytical Instrument Qualification guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity; handle in a controlled environment with desiccant protection. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	[M+H]+ m/z 596.3 ± 0.5 (calculated for C24H37F3N5O8)
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	Single impurity ≤1.0%; Total impurities ≤3.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	MeOH ≤3000 ppm; Acetonitrile ≤410 ppm; TFA ≤5000 ppm
Endotoxin	<1.0 EU/mg
pH (1 mg/mL, water)	3.5 – 5.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.