Description

Thiotolyl β-D-Ribofuranoside is a specialized nucleoside derivative, a key building block in synthetic organic chemistry and pharmaceutical research. Its value lies in its role as a crucial intermediate for the synthesis of modified nucleosides and nucleotides, which are essential for developing novel therapeutic agents and biochemical probes. This compound is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on antiviral drug discovery, oligonucleotide synthesis, and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleic acid biochemistry.
• Oligonucleotide Synthesis: Serves as a modified building block for the solid-phase synthesis of antisense oligonucleotides and siRNAs with enhanced properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic candidates targeting viral polymerases and other enzymes.
• Diagnostic Probe Development: Utilized in creating labeled nucleosides for diagnostic assays and imaging techniques.
• Glycoscience Research: Acts as a valuable intermediate for studying glycosylation reactions and synthesizing complex carbohydrate mimetics.

Basic Information

Product Name	Thiotolyl β-D-Ribofuranoside
CAS No.	1131610-84-8
Molecular Formula	C12H16O4S
Molecular Weight	256.32 g/mol
Synonyms	1-(4-Methylphenyl)sulfanyl-1-deoxy-β-D-ribofuranose; 1-Thio-β-D-ribofuranose 1-(4-methylbenzenesulfonate); p-Tolyl 1-thio-β-D-ribofuranoside; 4-Methylphenyl 1-thio-β-D-ribofuranoside; Thiotolyl-β-D-riboside; β-D-Ribofuranoside, 1-(4-methylphenyl)thio-; 1-Deoxy-1-[(4-methylphenyl)thio]-β-D-ribofuranose
EINECS	Contact for details

Quality Control

Our Thiotolyl β-D-Ribofuranoside is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.