Description

4-Fluoro-3-(trifluoromethyl)benzoyl bromide is a high-value, multi-fluorinated benzoyl bromide derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and a trifluoromethyl group, is engineered to impart unique electronic and steric properties to target molecules, enhancing their metabolic stability and lipophilicity. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with improved performance profiles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to enhanced biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, improving charge transport and stability in display technologies.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability for specialty plastics and coatings.
• Cross-Coupling Reactions: Functions as an efficient electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Peptide & Protein Labeling: Utilized as an acylating agent for selective modification of amino groups in biomolecules for research and diagnostic applications.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)benzoyl bromide
CAS No.	1131605-30-5
Molecular Formula	C8H3BrF4O
Molecular Weight	271.01 g/mol
Synonyms	4-Fluoro-3-(trifluoromethyl)benzoyl bromide; 3-Trifluoromethyl-4-fluorobenzoyl bromide; 4-Fluoro-alpha,alpha,α-trifluoro-m-toluoyl bromide; Benzoyl bromide, 4-fluoro-3-(trifluoromethyl)-; m-Trifluoromethyl-p-fluorobenzoyl bromide
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-(trifluoromethyl)benzoyl bromide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC/NMR), impurity profiles, and physical characteristics. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable integration into your critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.