Description

Glesatinib (Hydrochloride) is a potent and selective small-molecule inhibitor targeting specific tyrosine kinases, primarily developed for advanced oncology research. This compound matters as a critical tool for investigating novel therapeutic pathways in cancers driven by MET and AXL signaling, offering high biochemical potency and selectivity. Pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on precision medicine and targeted cancer therapy are the primary users of this high-purity reference standard.

Application

• Pharmaceutical Reference Standard: For use in analytical method development, validation, and quality control (QC) of drug substances and products.
• Preclinical Cancer Research: As a key biochemical tool for in vitro and in vivo studies targeting MET and AXL receptor tyrosine kinases.
• Mechanism of Action Studies: To elucidate signaling pathways, drug resistance mechanisms, and potential combination therapies in oncology.
• High-Throughput Screening (HTS): As a control compound in assays designed to discover new kinase inhibitors or validate screening platforms.
• Biomarker Development: Supporting research into predictive biomarkers for patient stratification in clinical trials.
• Formulation Development: Used in early-stage studies for solubility, stability, and dosage form development of novel drug candidates.

Basic Information

Product Name	Glesatinib (Hydrochloride)
CAS No.	1123838-51-6
Molecular Formula	C₂₉H₃₀ClN₇O₂ • HCl
Molecular Weight	572.52 g/mol
Synonyms	MGCD-265; MGCD265; MGCD 265; Glesatinib hydrochloride; Glesatinib HCl; N-[4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide hydrochloride; 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Glesatinib (Hydrochloride) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (on anhydrous basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.