Description

Sitravatinib CAS NO 1123837-84-2 is a potent and selective small molecule inhibitor targeting receptor tyrosine kinases, primarily designed for advanced pharmaceutical research and development. This compound is of significant interest for its potential in modulating key signaling pathways involved in oncology and immunology. It is an essential intermediate and active pharmaceutical ingredient (API) for researchers and manufacturers developing novel therapeutic agents in the biopharmaceutical sector.

Application

• Oncology Research: Primary application in preclinical and clinical research for investigating its efficacy against various cancer types, including renal cell carcinoma and non-small cell lung cancer (NSCLC).
• Immuno-oncology Development: Used in studies focusing on tumor microenvironment modulation and combination therapies with immune checkpoint inhibitors.
• Pharmaceutical Synthesis: Serves as a critical intermediate or the final Active Pharmaceutical Ingredient (API) in the manufacturing of investigational new drugs.
• Biochemical Assays: Utilized as a reference standard or a pharmacological tool in high-throughput screening and kinase profiling assays.
• Mechanistic Studies: Employed in academic and industrial research to elucidate signaling pathways involving TAM (TYRO3, AXL, MERTK) family receptors and VEGFR.

Basic Information

Product Name	Sitravatinib
CAS No.	1123837-84-2
Molecular Formula	C₃₁H₃₂N₈O₂
Molecular Weight	548.64 g/mol
Synonyms	MGCD516; MGCD-516; MG 516; Sitravatinib malate; (S)-N-(3-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; 1,1-Cyclopropanedicarboxamide, N-[3-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-, (1S)-; UNII-9M3H5W51AX
EINECS	Contact for details

Quality Control

Our Sitravatinib is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in preclinical and clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.