Description

N4-Benzoyl-5-(Furan-2-Yl)-2’-Deoxycytidine is a chemically modified nucleoside analog, specifically a protected derivative of 2'-deoxycytidine. This compound is of significant interest in pharmaceutical research and development, particularly in the synthesis of oligonucleotides and as a key building block for novel therapeutic agents. It serves as a critical intermediate for researchers and manufacturers in the fields of antiviral drug discovery, antisense oligonucleotide (ASO) synthesis, and medicinal chemistry. The strategic functionalization of the cytidine base and sugar moiety makes it a versatile precursor for creating targeted nucleotide-based therapies.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A crucial phosphoramidite or solid-phase synthesis building block for developing therapeutic ASOs targeting genetic diseases.
• Antiviral Drug Development: Serves as a modified nucleoside precursor in the research and production of potential antiviral compounds, including those targeting DNA viruses.
• Medicinal Chemistry & Lead Optimization: Used as a sophisticated intermediate to introduce specific modifications into nucleoside scaffolds for structure-activity relationship (SAR) studies.
• Biochemical Research: Employed in studies investigating DNA replication, repair mechanisms, and enzyme-substrate interactions using modified nucleotide probes.
• Prodrug Synthesis: The benzoyl and furan modifications can be utilized in designing prodrugs of nucleoside analogs to enhance bioavailability and targeting.
• Diagnostic Probe Development: Can be incorporated into oligonucleotide probes for diagnostic assays, leveraging its unique structure for specific binding or detection.

Basic Information

Item	Detail
Product Name	N4-Benzoyl-5-(Furan-2-Yl)-2’-Deoxycytidine
CAS No.	1119734-59-6
Molecular Formula	C20H19N3O6
Molecular Weight	397.38 g/mol
Synonyms	5-(2-Furyl)-N4-benzoyl-2'-deoxycytidine; 2'-Deoxy-N4-benzoyl-5-(2-furyl)cytidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(furan-2-yl)-4-(benzoylamino)pyrimidin-2-one; N4-Benzoyl-5-(2-furyl)-2'-deoxycytidine; 5-(2-Furanyl)-N4-(phenylcarbonyl)-2'-deoxycytidine; Modified 2'-Deoxycytidine Derivative; Bz-F-dC
EINECS	Contact for details

Quality Control

Our N4-Benzoyl-5-(Furan-2-Yl)-2’-Deoxycytidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, assay results, and impurity profiles. Our commitment to quality supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.