Description

Duocarmycin is a potent synthetic analog of the naturally occurring antitumor antibiotic, belonging to the cyclopropapyrroloindole (CPI) family of DNA alkylating agents. Its core value lies in its exceptional ability to form highly cytotoxic DNA adducts, making it a compound of significant interest for advanced pharmaceutical research and development. This product is essential for research scientists and organizations focused on oncology drug discovery, antibody-drug conjugate (ADC) development, and the study of DNA damage and repair mechanisms.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent warhead in the development of next-generation targeted cancer therapies.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies investigating novel chemotherapeutic agents.
• Mechanistic Studies: A critical tool for studying sequence-selective DNA alkylation, DNA minor groove binding, and cellular apoptosis pathways.
• Pharmaceutical Intermediate: Employed in the synthesis of more complex duocarmycin analogs and prodrugs with tailored pharmacological properties.
• Bioconjugation Chemistry: Utilized in developing linker-payload constructs for evaluating novel conjugation technologies and stability.

Basic Information

Product Name	Duocarmycin
CAS No.	1116745-06-2
Molecular Formula	C30H31N5O6
Molecular Weight	557.60 g/mol
Synonyms	Duocarmycin SA; (+)-Duocarmycin SA; CC-1065 analog; Cyclopropapyrroloindole analog; DNA alkylator; ADC payload DSA; (1S,8S)-1-(2-{[(2S)-1-{(3aS,4S,6S,7aR)-Hexahydro-1,3-dioxo-4,6-methano-5H-isoindol-5-yl}-1-oxo-3-phenylpropan-2-yl]amino}-2-oxoethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our Duocarmycin is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant guidelines for advanced pharmaceutical intermediates, ensuring traceability and reliability for critical research pathways.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.