Description

Dacomitinib (PF-299804) is a potent, irreversible, second-generation inhibitor of the human epidermal growth factor receptor (HER) family of tyrosine kinases, specifically targeting EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4). This small molecule pharmaceutical intermediate is critical for the research and development of targeted cancer therapies, particularly for non-small cell lung cancer (NSCLC). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers engaged in oncology drug discovery and development.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel EGFR/HER2-targeted oncology therapeutics.
• Preclinical & Clinical Studies: Used in formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and as a biomarker in investigative cancer research.
• Biochemical Research: Employed as a selective tool compound in cell-based assays and enzymatic studies to investigate HER family signaling pathways and mechanisms of drug resistance.
• Process Chemistry & Scale-Up: Acts as a critical building block for process chemists during the optimization and scale-up of synthetic routes for commercial API manufacturing.
• Quality Control & Analytical Testing: Functions as a high-purity certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Item	Details
Product Name	Dacomitinib (PF299804)
CAS No.	1110813-31-4
Molecular Formula	C24H25ClFN5O2
Molecular Weight	469.94 g/mol
Synonyms	PF-299804; PF299804; PF 299804; Vizimpro; (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-{[(3S)-oxolan-3-yl]oxy}quinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
EINECS	Contact for details

Quality Control

Our Dacomitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.