Description

Entrectinib is a potent and selective small-molecule inhibitor of the tyrosine kinases ROS1, ALK, and TRK A/B/C. This targeted therapeutic agent is crucial for advancing precision oncology research and development. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on developing novel treatments for solid tumors and other cancers driven by specific genetic alterations.

Application

• Pharmaceutical R&D: A key active pharmaceutical ingredient (API) and reference standard in the development of targeted cancer therapies.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the efficacy and mechanisms of TRK, ROS1, and ALK inhibition.
• Biochemical Assays: Serves as a critical tool compound in high-throughput screening and kinase profiling assays.
• Clinical Trial Material: Supplied as a high-purity intermediate for the formulation of clinical trial supplies.
• Academic Research: Enables basic and translational research into oncogenic signaling pathways and drug resistance mechanisms.

Basic Information

Product Name	Entrectinib
CAS No.	1108743-60-7
Molecular Formula	C31H34F2N6O2
Molecular Weight	560.64 g/mol
Synonyms	RXDX-101; NMS-E628; NMS-E-628; N-(5-(3,5-Difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide; UNII-8K713B0Y5U
EINECS	Contact for details

Quality Control

Our Entrectinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade and pharmaceutical intermediate specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.