Description

2'-β-C-Methyl-4-Thiouridine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in the discovery of nucleoside-based drugs targeting RNA viruses and specific cellular pathways. The product is supplied with a high level of purity to meet the stringent requirements of advanced medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of modified nucleoside antiviral agents.
• Antiviral Drug Research: Used in the study and synthesis of potential therapeutics targeting hepatitis C virus (HCV) and other RNA viruses.
• Medicinal Chemistry: Serves as a building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to viral polymerases and cellular nucleoside metabolism.
• Preclinical Development: Used in the synthesis of candidate compounds for in vitro and in vivo efficacy and toxicity testing.
• Process Chemistry: Acts as a starting material for scaling up the synthesis of advanced drug candidates under GMP-like conditions.

Basic Information

Product Name	2'-β-C-Methyl-4-Thiouridine
CAS No.	1106032-94-3
Molecular Formula	C11H16N2O5S
Molecular Weight	288.32 g/mol
Synonyms	2'-C-Methyl-4-thiouridine; 4-Thio-2'-C-methyluridine; 2'-β-C-Methyl-4-thiouridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-thioxo-1,2,3,4-tetrahydropyrimidin-2-one; 4-Thio-2'-methyluridine; 2'-Methyl-4-thiouridine
EINECS	Contact for details

Quality Control

Our 2'-β-C-Methyl-4-Thiouridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain product integrity and prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.