Description

5’-o-Dimethoxytrityl-N2-(Dimethylaminomethylidene)-8-Ethenyl-2’-Deoxyguanosine is a sophisticated, protected nucleoside derivative essential for oligonucleotide synthesis, particularly in the development of antisense therapeutics and diagnostic probes. This compound is a critical building block that enables the precise assembly of modified DNA sequences, offering researchers control over hybridization properties and stability. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on advanced genetic medicine and molecular biology.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of modified DNA strands.
• Antisense Drug Development: Used to incorporate modified guanosine bases into oligonucleotides designed for gene silencing and therapeutic applications.
• Diagnostic Probe Fabrication: Essential for creating high-specificity probes used in PCR, FISH, and microarray technologies.
• Research on Nucleic Acid Chemistry: Serves as a valuable intermediate in academic and industrial labs studying DNA structure, function, and modification.
• Synthesis of Aptamers: Employed in the production of engineered nucleic acid molecules for therapeutic and sensing purposes.

Basic Information

Product Name	5’-o-Dimethoxytrityl-N2-(Dimethylaminomethylidene)-8-Ethenyl-2’-Deoxyguanosine
CAS No.	1101864-07-6
Molecular Formula	C38H40N6O6
Molecular Weight	676.76 g/mol
Synonyms	8-Vinyl-dG(DMT) Amidite Precursor; 5'-O-(4,4'-Dimethoxytrityl)-N2-((dimethylamino)methylene)-8-ethenyl-2'-deoxyguanosine; DMT-8-Vinyl-2'-deoxyguanosine; N2-Dimethylaminomethylene-8-vinyl-2'-deoxyguanosine DMT protected; 8-Ethenyl-2'-deoxyguanosine DMT derivative; Protected 8-Vinyl-deoxyguanosine; DMTr-8-Vinyl-dG
EINECS	Contact for details

Quality Control

Our production of this high-purity building block adheres to stringent GMP-grade guidelines to ensure batch-to-batch consistency for sensitive research and development applications. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.