Description

Tepotinib CAS NO 1100598-32-0 is a highly selective, potent, and orally bioavailable small molecule inhibitor targeting the mesenchymal-epithelial transition (MET) tyrosine kinase receptor. This compound is of significant commercial and research interest as a targeted therapeutic agent, primarily developed for the treatment of non-small cell lung cancer (NSCLC) and other solid tumors exhibiting MET dysregulation. It is an essential raw material and reference standard for pharmaceutical R&D, clinical research, and the manufacturing of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as the core chemical entity in the commercial production of the targeted cancer therapy Tepotinib.
• Oncology Research & Drug Discovery: Used as a critical reference standard and biochemical tool in preclinical studies to investigate MET signaling pathways and tumor biology.
• Clinical Trial Material (CTM) Manufacturing: Supplied as a high-purity intermediate for the GMP-compliant production of materials used in human clinical trials.
• Analytical Method Development & Validation: Employed as a certified reference standard in HPLC, LC-MS, and NMR for quality control and impurity profiling.
• Mechanism of Action (MoA) Studies: Utilized in cellular and enzymatic assays to study inhibition kinetics, selectivity, and resistance mechanisms.
• Formulation Development: Acts as a key component in the development of stable and bioavailable dosage forms, such as tablets or capsules.

Basic Information

Product Name	Tepotinib
CAS No.	1100598-32-0
Molecular Formula	C29H28N6O2
Molecular Weight	492.58 g/mol
Synonyms	Tepotinib; MSC2156119J; EMD 1214063; EMD-1214063; 3-[1-[(2,6-Dichlorophenyl)methyl]-6-[(1R,5S)-3-(2-pyrimidinyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-1H-benzimidazol-2-yl]-2,2-dimethylpropanoic acid; 2,2-Dimethyl-3-[1-[(2,6-dichlorophenyl)methyl]-6-[(1R,5S)-3-pyrimidin-2-yl-3,8-diazabicyclo[3.2.1]oct-8-yl]benzimidazol-2-yl]propanoic acid
EINECS	Contact for details

Quality Control

Our Tepotinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical research and development. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.