Description

2-Chloro-5-(Trifluoromethyl)Pyridine-3-Carbonylchloride is a high-purity, reactive chemical intermediate essential for advanced synthesis. This compound matters because it serves as a critical building block for introducing the 2-chloro-5-(trifluoromethyl)pyridine moiety into complex molecular architectures. Pharmaceutical, agrochemical, and material science R&D teams need it for developing novel active ingredients, leveraging its unique halogenated and fluorinated structure to fine-tune biological activity and physical properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl and chloro groups enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Used in organometallic chemistry to create specialized ligands for catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate for synthesizing functionalized polymers, liquid crystals, and electronic materials requiring specific halogenated aromatic components.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom scale-up projects and proprietary molecule development.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Pyridine-3-Carbonylchloride
CAS No.	1099597-75-7
Molecular Formula	C7H2Cl2F3NO
Molecular Weight	243.99 g/mol
Synonyms	3-Chlorocarbonyl-2-chloro-5-(trifluoromethyl)pyridine; 2-Chloro-5-(trifluoromethyl)nicotinoyl chloride; 2-Chloro-5-(trifluoromethyl)pyridine-3-carbonyl chloride; 2-Chloro-5-trifluoromethylpyridine-3-carboxylic acid chloride; 3-Pyridinecarbonyl chloride, 2-chloro-5-(trifluoromethyl)-; 1099597-75-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Pyridine-3-Carbonylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.