Description

n-(4,4'-Dimethoxytrityl)-8-Nitroguanosine 2',3',5'-Triacetate is a sophisticated, high-purity nucleoside derivative designed for advanced synthetic applications. This compound serves as a critical, protected intermediate in the synthesis of oligonucleotides, enabling precise control over nucleic acid structure and function. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable building blocks for antisense therapeutics, primers, and probes.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• Diagnostic Probe Manufacturing: Enables the creation of highly specific labeled probes for PCR, sequencing, and microarray technologies.
• Biochemical Research: A valuable tool for studying nucleic acid interactions, enzyme mechanisms, and gene function.
• Synthesis of Nucleoside Analogs: Acts as a protected intermediate for further chemical modifications to create novel nucleoside derivatives.

Basic Information

Product Name	n-(4,4'-Dimethoxytrityl)-8-Nitroguanosine 2',3',5'-Triacetate
CAS No.	1096020-94-8
Molecular Formula	C41H40N6O13
Molecular Weight	824.79 g/mol
Synonyms	8-Nitro-DMT-Guanosine Triacetate; 8-Nitroguanosine, 2',3',5'-tri-O-acetyl-N-(4,4'-dimethoxytrityl)-; DMT-8-Nitro-Guanosine-2',3',5'-Triacetate; 2',3',5'-Tri-O-acetyl-8-nitroguanosine 5'-(4,4'-dimethoxytrityl) ether; N-DMT-8-Nitroguanosine Triacetate; Guanosine, 2',3',5'-triacetate, N-(4,4'-dimethoxytrityl)-8-nitro-; 1096020-94-8
EINECS	Contact for details

Quality Control

Our production of n-(4,4'-Dimethoxytrityl)-8-Nitroguanosine 2',3',5'-Triacetate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research and cGMP manufacturing. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.